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Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol.

Department of Nutrition, Food Science and Gastronomy, XIA, School of Pharmacy and Food Sciences, INSA, University of Barcelona, 08028 Barcelona, Spain. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain. Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA. Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, 46010 Valencia, Spain. Unitat de Nutrició Humana, Departament de Bioquímica i Biotecnologia, Hospital Universitari San Joan de Reus, Universitat Rovira i Virgili, 43201 Reus, Spain. Institut d'Investigació Sanitària Pere Virgili (IISPV), 43201 Reus, Spain. Cardiovascular Epidemiology Unit, Municipal Institute for Medical Research (IMIM), 08007 Barcelona, Spain. Research Unit, Department of Family Medicine, Distrito Sanitario Atención Primaria Sevilla, 41010 Sevilla, Spain. Department of Cardiology, Hospital Txangorritxu, 01009 Vitoria, Spain. Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), 07122 Palma de Mallorca, Spain. Department Clinical Sciences, University of Las Palmas de Gran Canaria, 35016 Palmas de Gran Canaria, Spain. Lipid Unit, Department of Internal Medicine, IDIBELL-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, FIPEC, 08908 Barcelona, Spain. Department of Epidemiology, School of Medicine, University of Malaga, 29010 Málaga, Spain. Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain. Internal Medicine Department, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain.

Nutrients. 2021;(8)
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Abstract

Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 μg/mg (-5.54, -0.71), p-value = 0.016 and -3.03 μg/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.

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Publication Type : Multicenter Study

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